How to Use Keytweak. KeyTweak is a computer application that allows you to modify the inputs of keys. This helpful tool can make one key do a different thing than it's supposed to as well as disable keys- useful changes that are good when...Other voices. KeyTweak […] achieves the seemingly impossible: Edit a keyframed mask globally simply by points on one or two mask keyframes, and the rest are automagically changed 'accordingly'. Free download KeyTweak for Windows 10. KeyTweak enables you to customize your keyboard and assign different functionality to selected keys. The program is easy to use and offers a virtual keyboard display, that you can use to select the key, and then simply assign a new...KeyTweak is a simple utility that allows users to redefine their keyboard input signals. The functionality is made possible by a registry value first documented in Windows 2000, but also present in Windows NT 4.0. and included in XP, Vista and Windows 7.